The HCC cell-secreted exosomes circUHRF1 can inhibit the function of NK cells, promote the immune escape of HCC cancer, and increase the resistance of anti-PD1 immunotherapy through the miR-449c-5p/TIM-3 pathway, which provide a novel therapeutic approach for HCC patients, that is, targeting circUHRF1 (105). This evidence concerns the gene HAVCR2 and hepatocellular carcinoma.