FOXO1 and gastric cancer: circMRPS35 is lowly expressed in gastric cancer, and it can serve as a protein scaffold to recruit histone acetyltransferase KAT7 to the promoters of FOXO1 and FOXO3a genes to further cause H4K5 acetylation, which further activate the transcription of FOXO1 and FOXO3a and trigger the expression of their downstream targets (p21, p27, Twist1 and E-cadherin genes), thereby inhibiting the proliferation and invasion of gastric cancer cells (80).