AKT1 and pancreatic ductal adenocarcinoma: circBFAR, with high expression in pancreatic ductal adenocarcinoma, up-regulates the expression of mesenchymal-epithelial transformation (EMT) through sponge adsorption of miR-34b-5p to phosphorylate Akt at Ser 473, which further activates MET/PI3K/Akt signal transduction pathway to promote the proliferation, migration and invasion of pancreatic ductal adenocarcinoma (73).