Indeed, two gene expression profiles have been found: a DLL3high/Notchlow profile with high expression levels of neuroendocrine genes (synaptophysin, chromogranin A) in LCNEC with TP53 and STK11/KEAP1 mutations and, on the other hand, a DLL3low/Notchhigh gene expression profile and lower expression levels of neuroendocrine genes in LCNEC with TP53 and RB1 mutations. Here, KEAP1 is linked to large cell neuroendocrine carcinoma.