For instance, it has been reported that LINC-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b (21).Hao et.al found that LINC-PINT suppresses tumor cell proliferation, migration and invasion through targeting miR-374a-5p in ovarian cancer (22).Previous study has proved that LINC00518 serves as a sponge for the miR-204-5p in melanoma (12). Here, SMAD7 is linked to melanoma.