CTLA4 and neoplasm: Tim3 (T cell immunoglobulin and mucin domain-containing protein 3), Lag3 (lymphocyte activation gene 3), Pdl1 (programmed death ligand 1), and Mhc1 (major histocompatibility complex-1), which are genes that regulate tumor cell immune susceptibility, were significantly increased in the tumors of mice treated with RT, BEMPEG, and anti-CTLA-4 (Figure 3E).