IL2 stimulates proliferation of CD8 T cell and NK cells through the binding of the intermediate affinity IL2βγ receptor, but it also interacts with the high affinity trimeric IL2αβγ receptor leading to the expansion of regulatory T cells (Tregs), which can be immunosuppressive in the tumor microenvironment (TME) (20, 26). Here, CD8A is linked to neoplasm.