TWIST1 and cancer: Several critical EMT-inducing transcription factors (EMT-TFs), which include zinc-finger E-box binding homeobox 1 (ZEB1), ZEB2 (also known as SIp1), Snail1 (also known as Snail), Slug (also known as Snail2) and Twist-related protein 1(Twist1; also known as Twist), have been demonstrated to play significant regulatory roles in the EMT program of cancer cells (74).