RES significantly attenuated 5-FU-induced EMT by down-regulation of NF-κB activation, which is proved by the evidence that RES suppresses EMT factors (down-regulating the expression of Slug and vimentin as well as up-regulating of E-cadherin) and overexpresses the gap and tight junctions (claudin-2) in colorectal cancer cells (15). The gene discussed is CDH1; the disease is colorectal cancer.