PTEN and gastric cancer: For example, miR-193-3p (19), miR-147 (20), miR-106a (21), miR-21-5p (22), and miR-19a /b (23) are all highly expressed in drug-resistant GC cell lines, and reducing their expression will inhibit the PI3K/Akt cellular signal transduction pathway of by promoting the expression of PTEN, thus promoting the apoptosis of GC cells.