Zhang HY (66) showed that cisplatin and paclitaxel promoted exosomal miR-522 secretion from CAFs (cancer-associated fibroblasts), leading to ALOX15 (arachidonate lipoxygenase 15) suppression and decreased lipid-ROS (toxic lipid peroxides) accumulation in GC cells, and ultimately result in decreased chemo-sensitivity. Here, ALOX15 is linked to gastric cancer.