The western blotting results of related pathway proteins showed that p62KO promoted the phosphorylation of AKT, inhibited the expression of AMPK and caused the activation of mTOR, which made it difficult for autophagy to be started and led to autophagy inhibition, indicating that p62 played a role in inducing autophagy in papillary thyroid carcinoma. The gene discussed is AKT1; the disease is differentiated thyroid carcinoma.