Nevertheless, it was reported that p62 also participates in many cellular biological activities, such as the cell cycle, cell metabolism (18), the scavenging effect of selenium on peroxy radicals, etc. Mutations in the p62 gene are strongly associated with Paget’s disease of the bone (19), murine myeloid leukemia progression (20), neurodegenerative disease (21), obesity (22), vascular senescence (23), aging pathologies and cancer (24, 25). Here, SQSTM1 is linked to obesity due to melanocortin 4 receptor deficiency.