TP53 and small cell lung carcinoma: As TP53 is inactivated in most SCLC, Fernandez-Cuesta and colleagues (95) assessed the presence of exon 2 to 10 mutations in plasma cfDNA from 51 SCLC patients and 123 controls and showed that, despite their occurrence in control samples due to interference of somatic mutations, they were significantly more frequent in SCLC cases, even when stratified by stage (95).