CTBP1 and reading: Through the Gene Expression Profiling Interactive Analysis (GEPIA) (http://gepia.cancer-pku.cn/), a newly developed interactive web server for analyzing the RNA-sequencing expression data of 9,736 tumors and 8,587 healthy samples from the The Cancer Genome Atlas and the Genotype Tissue Expression projects (14), we found that CTBP1-AS2 upregulation also occurred in most tumor tissues (Supplementary Figure 1B), including colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ) (Figure 1B).