Thus far, genome-wide association studies (GWAS) have identified around 100 loci associated with sporadic CRC, in or proximal to known CRC-related genes and pathways (e.g., BMP2, BMP4, SMAD7, CCND2, GREM1) and in genes not previously linked to CRC (CDKN1A, EIF3H, TPD52L3, ITIH2, LAMA5, and LAMC1) (6, 7). Here, GREM1 is linked to colorectal carcinoma.