In tumor cells, we found significant correlations between CHI3L2 expression and WHO grade (P<0.001), age (P=0.001), Ki67 (P<0.001), P53 (P=0.034), PHH3 (mitotic figures) (P<0.001), ATRX protein expression (P=0.026), IDH (P<0.001) and 1p/19q codeleted (P=0.002). This evidence concerns the gene TP53 and neoplasm.