CHI3L2 and central nervous system cancer: In univariate analysis, CHI3L2 expression in tumor cells, CHI3L2+ macrophage cells density, CHI3L2 expression in both tumor cells and macrophage cells (TC + MC), grade, age, location, adjuvant therapy, Ki67 index, PHH3 (mitotic figures), IDH, and 1p/19q codeleted status were shown to be prognostic variables for the prognosis of overall survival in glioma patients (Table 2).