When considering the CHI3L2 expression of tumor cells and macrophages together, we found the overall survival time was higher in patients with dual-low CHI3L2 expression in TC and MC compared to those in patients with non-dual CHI3L2 expression and dual high expression in DIG (Figure 3G), but this difference is not statistically significant in LGG and GBM (Figures 3H, I). Here, CHI3L2 is linked to neoplasm.