In the univariate analysis, the clinical and pathological features associated with shorter OS were men (P = 0.048), tumor size ≥ 5 cm (P = 0.008), lymph node metastases (P = 0.005), distant metastases (P < 0.001), without chemotherapy (P = 0.003), B7-H3 positive expression (P = 0.008), and B7-H4 positive expression (P = 0.024) (Table 3). This evidence concerns the gene CD276 and metastatic malignant neoplasm in the lymph nodes.