CXCR4 and acute myeloid leukemia: In the leukemic hematopoietic microenvironment (LHME) in MLL-AF9-induced mouse acute myeloid leukemia (AML) model, CCL3-CCR1/CCR5 and CXCL12-CXCR4 inhibition block leukemia progression by impairing Tregs migration (135).