TGFB1 and neoplasm: Our GSEA enrichment analysis showed that the high-risk group with higher mortality than the low-risk group had a mainly positive role in the relevant mechanisms of tumor cells, including the Notch, VEGF, WNT, MAPK, and TGF-β signaling pathways, 11 autophagy associated genes may be related to the biological pathway related to CRC, and its dysfunction may lead to poor prognosis of CRC.