Our GSEA enrichment analysis showed that the high-risk group with higher mortality than the low-risk group had a mainly positive role in the relevant mechanisms of tumor cells, including the Notch, VEGF, WNT, MAPK, and TGF-β signaling pathways, 11 autophagy associated genes may be related to the biological pathway related to CRC, and its dysfunction may lead to poor prognosis of CRC. This evidence concerns the gene VEGFA and colorectal carcinoma.