In addition to the upstream regulatory role of MYCN in lipid metabolism reprograming of cancer cells [reviewed in (57)], inhibition of lipid desaturation using both genetic and pharmacological approaches against SCD1 reduced MYCN gene expression and selectively suppressed the proliferation of high MYCN-expressing HCC cells, suggesting a direct regulatory role of lipid desaturation on MYCN transcription (56). This evidence concerns the gene MYCN and hepatocellular carcinoma.