Furthermore, elevated CRP, D-dimer and IL-6 have been associated with severe COVID-19 based on meta-analysis studies.13,56 Thirdly, exhaustion of T-cell lymphocytes, which is observed in HIV progression, may also be exacerbated during COVID-19 infection, possibly as a result of the SARS-Cov-2 infection’s synergistic activity with HIV, which gradually results in T-cell lymphocyte apoptosis.57 This exhaustion of T-cell lymphocytes was associated with the progression and severe manifestation of COVID-19.58,59. The gene discussed is CRP; the disease is COVID-19.