By using the multiple regression analysis, ACR, MDA, hs-CRP, TNF-α, SOD3, PON-1, eNOS, and SDF-1α were found to be related to independent risk indicators of complex reocclusion lesions following different lengths of coronary stent implantation after adjustment for age, gender, type II diabetes, coronary heart disease, hypertension, myocardial infarction, angina pectoris, dyslipidaemia, married, unmarried, obesity, and target lesion revascularization in the patients complex reocclusion lesions. The gene discussed is CXCL12; the disease is obesity due to melanocortin 4 receptor deficiency.