Further studies have reported that FSTL-1 regulates the secretion of inflammatory factors such as interleukin-α, TNF-α, and ADAMTS and participates in the immune inflammatory response in tissues in many systemic autoimmune diseases, including systemic lupus erythematosus, ulcerative colitis, rheumatoid arthritis, and Sjogren's syndrome [24, 25]. The gene discussed is FSTL1; the disease is rheumatoid arthritis.