PCSK9 and hyperlipidemia: The expressions of Srebp-1c, Cyp3a9, and Insr mRNA were turning to a significant reversal (P< 0.01) in the H group when compared with the M group, which is consistent with the transcriptomic results, while Cyp7a1, Pcsk9, and Gck mRNA expression had no significant difference compared with rats with hyperlipidemia.