PLOD1 and premature menopause: Furthermore, a section of researchers found that Bushen Huoxue decoction can effectively improve the clinical symptoms of patients with POF, by adjusting FSH levels and FSH/LH ratios, increasing AMH levels, and adjusting ANA-ACA-AOA, ACT-INH-FS, and other pathways to alleviate symptoms through clinical randomized controlled trials (RCT).