The experiment of Li et al. [52] proved that a variety of active ingredients extracted from dodder-Lycium barbarum drugs may have an effect on treating POF through the PI3K/AKT signaling pathway, MAPK, and other pathways, and dug out the potential active ingredients like sterol, sesamin, and potential target IL-6 and TNF simultaneously. Here, AKT1 is linked to premature menopause.