Figures 4-A and 4-B show positive immunoreactivity of CK17 only in basal layer, which was negative in atypical squamous, and Figure 4-C shows positive cytoplasmic of CK17 in squamous metaplastic cells. P63 was found to be positive in 50.28% of all the case that 89.8% were diagnosed as dysplasia and 19.5% showed metaplasia. P16 was found to be positive in 29.78% of all the cases, of which 50.8% diagnosed as dysplasia. CK17 was found to be positive in 69.8% of all the case of which 8.5% showed dysplasia and 92.7% demonstrated metaplasia (Table 7). The gene discussed is KRT17; the disease is dysplasia.