Consistent with this finding, HUVEC treated with the conditioned media of MCT4 F98 glioma cells exhibited increased VEGF and VEGFR mRNA expression levels compared to those treated with the conditioned media of con, MCT4KD, and inhibitor-treated MCT4 F98 glioma cells (Figure 4(b)). Here, SLC16A3 is linked to central nervous system cancer.