Interestingly, in silico analysis of MCT4/SLC16A3 and HIF-1α/HIF1A expression in microdissected GBM tumor compartments obtained from the IVY Glioblastoma Atlas Project database [42] revealed an expression gradient for both genes from the leading edge towards the tumor center in most tumor specimens (Figure 1(d)). Here, SLC16A3 is linked to neoplasm.