In a pathological condition, mutated PARK2 gene encodes for loss-in-function Parkin protein, which disabled its degrading ability, thus increasing the risk of developing PD through mitochondrial dysfunction, α-synuclein aggregation, and LB formation (Selvaraj and Piramanayagam, 2019; Ge et al., 2020). This evidence concerns the gene PRKN and Parkinson disease.