It is demonstrated that NIFK-AS1 increases the expression of Notch1 by interacting with miR-146a in endometrial cancer (Zhou et al., 2018), and FGD5-AS1 affects periodontitis by regulating the FGD5-AS1/miR-142-3p/SOCS6 axis (Chen et al., 2019). This evidence concerns the gene NOTCH1 and periodontitis.