Of the 398 IHC pairs, multivariate Cox regression analyses showed that CSNK1E↓-SHC1(N)↓, CSNK1E↓-RB1(N)↑, and BRCA1(N)↓-SHC1(N)↓ were significant predictors of the risk of death in this Taiwanese OSCC population, independent of tumor stage. Here, RB1 is linked to neoplasm.