Interestingly, cytokine variants predispose to DHRs such as liver injury: IL10-592 AA and IL10-819 TT are associated with docetaxel-induced liver injury, and polymorphism-380G/A in TNF−α is associated with hepatitis induced by antituberculosis drugs (Kim et al., 2011a; Liang et al., 2013; Figure 1). This evidence concerns the gene IL10 and hepatitis A virus infection.