GJA1 and Alzheimer disease: Supplementary Figure 11 showed that the expression difference of PLXNB1 among Braak NFT stages of the AD in TC tissue was significant (P < 0.05). No difference was recorded in the expression levels of hub genes based on the Braak NFT stages of the AD in FC tissue (Supplementary Figure 12). The expression of GJA1 and GRAMD3 (Supplementary Figure 13) based on Braak NFT stages of AD in EC tissue was significantly different (P < 0.05). The detailed results of ANOVA analysis of gene expression among Braak NFT stages are as in Supplementary Table 6.