These examples demonstrate that eye disorders are not uncommon in patients with Xp11.22p11.23 duplication, however, only four genes as BCOR, NDP, NYX, and RP2 are known associated with abnormalities of the eyes and these are involved in the duplication of our Patient 1 and the case reported by Zou and Milunsky (2009). This evidence concerns the gene NYX and eye disorder.