Of interest, RTEL1 and the read-through transcript RTEL1-TNFRSF6B had been postulated to be target genes in 20q13.33 due to its role in telomere maintenance and also the fact that the top glioma GWAS risk allele resides within an intron of RTEL1 (rs2297440) (Melin et al., 2017). This evidence concerns the gene TNFRSF6B and central nervous system cancer.