Within 2q33.3, which is also a locus associated with IDH1-mutated glioma (Kinnersley et al., 2018), the target gene C2orf80 is 50 kb telomeric to IDH1, but whether or how C2orf80 interacts with IDH1 remains to be elucidated. Here, C2orf80 is linked to glioma.