CD4 and type 1 diabetes mellitus: Using a murine T1DM model induced by multiple injections of low-dose streptozotocin (STZ), Zhang W et al. reported that adoptive transfer of human GMSCs led to a robust control of blood glucose levels, delayed diabetes onset, ameliorated pathologic scores in pancreas, down-regulated production of IL-17 and IFN-γ in CD4+ and CD8+ T cells in spleens, pancreatic lymph nodes (pLN) and other lymph nodes as well as up-regulated levels of periphery CD4+ Treg (68).