The targeted elements include tumor cells, innate immune cells (macrophages, neutrophils, dendritic cells and NK cells), T and B lymphocytes, CAFs, ECM proteins (fibronectin, tenascin C), blood and lymphatic vessels and nerve fibers, together with markers of proliferation, maturation, immune checkpoint and epithelial-mesenchymal transition. The gene discussed is TNC; the disease is neoplasm.