As shown in Figure 3 with a ROI of a representative cSCC section, the panel allows the characterization of the overall tumor organization by targeting tumor cells (pan-cytokeratin), immune cells (CD45), ECM (fibronectin), blood vessels and CAFs (aSMA), lymphatic vessels (podoplanin) and nerves (pan-neurofilament). This evidence concerns the gene PDPN and neoplasm.