To date, various biomarkers, including tumor tissue PD-L1 (tPD-L1) expression, tumor mutation burden (TMB), tumor neoantigen burden (TNB), high microsatellite instability (MSI-high), deficient mismatch repair (dMMR), tumor-infiltrating lymphocytes (TIL), T-cell receptor clonality, effector T-cell gene signature, DNA damage and repair genes (DDR), intestinal microbiota, etc. have been demonstrated to be associated with a better response rate and prolonged survival (7–10). The gene discussed is CD274; the disease is neoplasm.