In the HIV+ group, we observed a specific signature characterized by higher plasma levels of IL-18, IL-1β, FLT3L, C-peptide, FGF-23, FSH and VEGF-A in individuals with compared to those without subclinical atherosclerosis (p=0.0016, 0.039, 0.0075, 0.035, 0.038, 0.049 and 0.0053, respectively, Figure 2A) combined with lower levels of IL-9, IFNβ and the TNF-related apoptosis inducing ligand (TRAIL) (p=0.0376, 0.0093 and 0.0149, respectively, Figure 2B). The gene discussed is BRD2; the disease is atherosclerosis.