However, the subclinical atherosclerosis-associated plasmatic signature in the HIVneg population was different and marked with the upregulation of TNF-α and IL-27 and downregulation of CCL26 and IL-17C (p=0.02, 0.043, 0.011 and 0.021, respectively) (Figure 2C). The gene discussed is IL27; the disease is atherosclerosis.