AR-R17779 has a protective role mediated by α7-nAChR in intestinal colitis and post-operative infections model (170, 171). In CFA-induced arthritis, it plays a contradictory role. It decreased TNF-α levels in plasma and synovial tissue, as well as exacerbates arthritis (172, 173). Here, CHRNA7 is linked to arthritic joint disease.