ITGAX and Alzheimer disease: Treg suppressive activity is enhanced post GAL incubation (77). GAL sensitizes microglial α7-nAChRs and induces Ca2+ influx signaling cascades that stimulate Aβ phagocytosis in the AD model (78) GAL resulted in reduced mucosal inflammation associated with decrease MHC II levels and proinflammatory cytokine secretion by splenic CD11c+ cells (79).