As shown in Figure 6A, ATP2C2 low-expression group’ genes were significantly enriched in immune-related activities, such as cytokine–cytokine receptor interaction, hematopoietic cell lineage and primary immunodeficiency, while those in ATP2C2 high-expression group were mainly enriched in metabolic pathways, including citrate cycle TCA cycle, amino sugar and nucleotide sugar metabolism, and fructose and mannose metabolism (Figure 6B). The gene discussed is ATP2C2; the disease is inborn error of immunity.