Similarly to EVs, a possible link was described between Rotaviruses – such as Rotavirus C (RVC) - and T1D, because of a potential molecular mimicry between the VP7 protein of a human rotavirus strain and I-A2 (35) and GAD65 (36), although in the latter case the response was limited to CD4+ T cells. The gene discussed is CD4; the disease is type 1 diabetes mellitus.