As shown in Figure 6A, in the discovery cohort, the dual combination of cytokines TNFα/IL-2 TNFα/IL-17A, IL-2/IL-17A, and triple combination of cytokines TNFα/IL-2/IL-17A showed good significant discriminatory power with high AUC, sensitivity and specificity in discriminating confirmed TB from unlikely TB children. Here, IL2 is linked to tuberculosis.