In order to validate whether transfer of exogenous IL-33 into the Treg-depleted mice will restore the Treg cells population and recover the activity of pulmonary epithelial regeneration, Treg-depleted mice were supplemented with recombinant IL-33 during ARDS, and the schematic diagrams were depicted in Figure 8A. The gene discussed is IL33; the disease is acute respiratory distress syndrome.