C5AR1 and vascular hemostatic disease: Although systemic inflammation was induced by this dose, no tissue damage was detected in the evaluated organs (brain, lungs, heart, kidneys, liver, and spleen) (37); however, this assessment does not exclude changes at the physiological level, since C5a binding to C5aR1 leads to blood pressure alteration (76), electrophysiological changes (77), pain (78), and hemostatic disorders (17, 79, 80).