ISG20 and COVID-19: In module 2, enhanced expression of glycolysis (GAPDH and TPI1) and IFN response (IFITM2, IFITM1, IFITM3, IFNGR2, and ISG20) genes in human COVID-19 patients, particularly severely ill patients, may promote the differentiation of unswitched memory B cells into plasmablasts (Figures 4D, E) (52).