Studies including ours have suggested a positive loop between RhoA/Rho-kinase signaling and TGFβ1 that drives airway constriction, airway hyper-responsiveness, and airway remodeling in asthma (38–41), raising the possibility that RhoA/Rho-kinase signaling may be one of the central pathways in regulating allergen-induced TGFβ1 activation. This evidence concerns the gene TGFB1 and asthma.