Regarding the CD27 in CD, reduced CD27- IgD- B cells in the blood and raised CD27- IgD- B cells was found in the gut-associated lymphoid tissue in IBD (26), study also observed that patients with CD were characterized by a reduced proportion of B cells of the memory CD27+ phenotype compared to the non-IBD controls (27). The gene discussed is CD27; the disease is inflammatory bowel disease.