HAVCR1 and Abnormal renal physiology: As shown in Figures 5D–I, the protective effect of LXA4 in reducing septic renal dysfunction was inhibited by GW9662, as evidenced by higher serum BUN and SCr, urinary KIM-1, and NGAL levels, and pathological scores in LXA4 + GW9662 + CLP group compared to those in LXA4 + CLP group (all p < 0.001).