IKZF1 and systemic lupus erythematosus: CRISPR/CAS9 genome editing validated novel SLE-associated regulatory elements that regulate TFH and SLE genes like BCL6, CXCR5, and IKAROS. A separate study combined the SNPs associated with 19 autoimmune diseases with cell-specific multi-omics approaches to develop an epigenetic weighted scoring method to evaluate the functionality of all noncoding autoimmune SNPs.