IL1RN and systemic lupus erythematosus: A more recent study in this field profiled six major immune types in SLE patients by single-cell RNAseq and found a unique set of genes in monocytes, including two well-known immune modulators for SLE and RA therapeutics (TNFSF13B/BAFF: belimumab and IL1RN: anakinra, respectively) (39).