Naïve T cells from SLE patients exhibit global hypomethylation due to decreased DNMT1 activity (55), with specific genes such as CD11a (ITGAL), perforin (PRF1), CD70 (TNFSF7), and CD40LG (TNFSF5) showing decreased DNA methylation (56). Here, PRF1 is linked to systemic lupus erythematosus.