In a study of lupus, researchers used a random forest machine learning method to integrate Immunochip genotyping and T and B cell RNA-seq analysis from SLE patients and healthy control subjects, identifying three novel genes (ZNF804A, CDK1, and MANF) that were not previously been associated with SLE or any other autoimmune disorder (48). This evidence concerns the gene CDK1 and systemic lupus erythematosus.