The monogenic immune disorder IPEX (Immunodysregulation, Polyendocrinopathy, Entereopathy, X-linked syndrome) provides an example of a breach in tolerance in which mutations in the forkhead box P3 (FOXP3) gene leads to loss of Treg and/or their function (14, 15). The gene discussed is FOXP3; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.