Indeed, CD8+CD103+FoxP3+ TGFβ producing Treg cells, which maintain lupus patients in long term immunological remission after autologous bone marrow transplantation (135), or that induced in lupus patients’ PBMC by the histone peptide epitopes in vitro (147), have their highly effective suppressor counterparts in several models of autoimmune diseases including lupus (148–151). This evidence concerns the gene FOXP3 and autoimmune disease.