IFNG and systemic lupus erythematosus: The Treg cells suppressed IFN-γ production by pathogenic lupus Th cells in response to nucleosomal epitopes at up to 1:100 ratio of Treg or Treg : Th cells, and diminished autoantibody production in vitro by up to 90-100% by inhibiting nucleosome-stimulated T cell help to nuclear autoantigen-specific B cells.