And the above category of CD8+FoxP3+ TGFβ producing Treg that are highly effective in controlling lupus disease, are quite different from another variety of CD8+ Treg that are FoxP3-negative, cytotoxic and contact-dependent, and with varying surface phenotypes found in organ-specific autoimmune diseases (141–143). This evidence concerns the gene FOXP3 and autoimmune disease.