Regulatory mechanisms against abnormal autoimmune response to nuclear autoantigens in asymptomatic subjects could be enforced by the relatively innocuous tolerance therapy with histone peptides (147), which suggests that apparently healthy relatives or ANA positive subjects at risk for developing lupus as predicted by GWAS bio-markers, could be protected prophylactically with these peptide epitopes. Here, BTG3 is linked to systemic lupus erythematosus.