These CD8+CD103+FoxP3+ TGFβ producing Treg are highly effective in controlling lupus, as shown in autologous stem cell transplant patients in remission above; and after corticosteroid pulse therapy induced remission in patients with lupus nephritis (Tsai YG et al. Plos One 2014, 9:e81344); as well as in murine models of lupus (108, 137, 138), and graft-versus-host lupus (138–140). The gene discussed is CD8A; the disease is lupus nephritis.