CD4 and systemic lupus erythematosus: Indeed, in PBMC cultures from inactive lupus patients and healthy subjects, addition of the histone peptide epitopes induced CD4+CD25highFoxP3+ or CD4+CD45RA+FoxP3low Treg cells, as well as CD8+CD25+FoxP3+ Treg cells with stable FoxP3 expression and suppressive activity (147).