CD4 and lupus nephritis: Anyway, target organ pathology in lupus nephritis, is inhibited by the TGFβ producing CD4+FoxP3+ Treg and CD8+FoxP3+ Treg cells induced by histone peptide epitope tolerance therapy (80, 108), or by targeted nanoparticle therapy (140) induced CD8+ Treg, which are quite different from the cytotoxic CD8 Treg (144, 145).