The histone peptide epitopes, administered S.C. in a very low doses, generate Treg cells that suppress by producing minute amounts of TGFβ that act in close range cell to cell interaction, rather than causing Th2 deviation with consequent allergic reactions seen in the case of therapy of other autoimmune diseases, such as, EAE/MS and diabetes in NOD mice using other peptides. Here, TGFB1 is linked to autoimmune disease.