Noteworthy, combinations of CpG plus RT, agonistic OX40 mAbs plus RT as well as CpG plus agonistic OX40 mAbs have shown synergistic effects in their ability to limit tumor growth, making the combination of CpG, agonistic OX40 with RT or other ablative therapies an interesting approach to explore (29, 70, 71). The gene discussed is TNFRSF4; the disease is neoplasm.