IFNG and vitiligo: We know that IFNγ is critical for the progression of vitiligo through 1) its induction of CXCL9 and CXCL10 chemokines and thereby recruitment of CD8+ T cells expressing CXCR3, which are without doubt responsible for the loss of melanocytes and 2) its direct effect together with TNFα on melanocyte, through induction of melanocyte detachment from the basal layer of the epidermis (43).