Activation of this cell subset is likely mediated by the release of DAMPs from epidermal cells, as shown with HSP70i, potentiating IFNα secretion by pDCs and subsequent production CXCL9 and CXCL10 chemokines by epidermal cells, leading to the Th1 adaptive immune response establishment characteristic of vitiligo skin (42). This evidence concerns the gene IFNA1 and vitiligo.