JCM1132 strain (bacteriocin-producer) reduced the proinflammatory cytokine IL-6 in mice. CCFM720 strain (non-bacteriocin-producer) decreased concentration of anti-inflammatory factor IL-10. Both strains showed low immunogenicity. No significant immune response was recorded. CCFM720 favored the prevention of metabolic diseases. JCM1132 showed weak inflammatory response in comparison to CCFM720-treated mice. This evidence concerns the gene IL6 and metabolic disease.