ADIPOQ and Insulin resistance: However, upregulation of adiponectin expression in muscles of obese and diabetic mice has been previously observed (75); the assessment of metabolic or inflammatory profile of subjects suffering from low muscle mass and impaired physical function revealed a more significant association with insulin resistance and elevated levels of C-reactive protein, IL-1, and IL-6 in obese patients than in subjects with normal or reduced BMI (76, 77).