While none of the associations with common PD-risk SNPs reach genome-wide significance (~5 × 10−8) (Tables 1, 2, Supplementary Tables 4, 5), gene-level tests using rare variants identify four associations with baseline clinical features that approach or reach significance for the number of mapped genes (2.81 × 10−6): TOX3 and SULT1C2 with UPDRS IV-total score, GPNMB with bradykinesia, CATSPER3 (73) with anxiety (Table 3, Supplementary Table 6). The gene discussed is TOX3; the disease is Parkinson disease.